Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.400 Therapeutic disease CTD_human [Interferon gamma as an immunological strategy for the treatment of human leishmaniasis]. 7854095 1994
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13 		0.010 AlteredExpression disease BEFREE While many IFN-inducible transcripts were upregulated in the infected spleen, fewer were induced in splenic macrophages in VL. 28141856 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1 		0.010 AlteredExpression disease BEFREE While many IFN-inducible transcripts were upregulated in the infected spleen, fewer were induced in splenic macrophages in VL. 28141856 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.010 GeneticVariation disease BEFREE We therefore investigated the possibility of using DNA-vaccination against Leishmania donovani infection with the A2 virulence gene and whether inhibiting the cellular p53 response could increase the effectiveness of the A2 DNA vaccine. p53, also known as the guardian of the genome, is activated following DNA transfection and has pleotropic effects on cells, which could have adverse effects on the effectiveness of DNA-vaccination. 11312013 2001
Entrez Id: 6556
Gene Symbol: SLC11A1
SLC11A1 		0.370 GeneticVariation disease BEFREE We therefore examined polymorphisms at SLC11A1 in 59 multicase families of VL from the high-incidence Masalit tribe in Sudan. 14523377 2004
Entrez Id: 4953
Gene Symbol: ODC1
ODC1 		0.020 GeneticVariation disease BEFREE We report here a Leishmania donovani ornithine decarboxylase (Ld-ODC) gene used as a DNA vaccine against visceral leishmaniasis in a murine Balb/c mouse model. 29558698 2018
Entrez Id: 3594
Gene Symbol: IL12RB1
IL12RB1 		0.020 Biomarker disease BEFREE We report a 5-year-old patient with IL-12Rbeta1 deficiency who developed recurrent visceral leishmaniasis 6 months apart. 17414409 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.400 Biomarker disease BEFREE We performed combined blockade of IFN-γ and TNF-α in VL splenic biopsies and demonstrated it's impact on number of viable amastigotes and cytokine production. 29953494 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.400 Biomarker disease BEFREE We performed combined blockade of IFN-γ and TNF-α in VL splenic biopsies and demonstrated it's impact on number of viable amastigotes and cytokine production. 29953494 2018
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.050 Biomarker disease BEFREE We optimized and assessed in vivo the safety and immunogenicity of an innovative vaccine candidate against human visceral leishmaniasis (VL), consisting of Virus-Like Particles (VLP) loaded with three different recombinant proteins (LJL143 from Lutzomyia longipalpis saliva as the vector-derived (VD) component, and KMP11 and LeishF3+, as parasite-derived (PD) antigens) and adjuvanted with GLA-SE, a TLR4 agonist. 29176865 2017
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.010 AlteredExpression disease BEFREE We observed that Leishmania donovani infection led to enhanced N-Ras expression, whereas it inhibited K-Ras and H-Ras expression. 29943842 2018
Entrez Id: 3578
Gene Symbol: IL9
IL9 		0.030 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		0.020 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 10314
Gene Symbol: LANCL1
LANCL1 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 115482699
Gene Symbol: H3P28
H3P28 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 9181
Gene Symbol: ARHGEF2
ARHGEF2 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 339541
Gene Symbol: ARMH1
ARMH1 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 10969
Gene Symbol: EBNA1BP2
EBNA1BP2 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 3921
Gene Symbol: RPSA
RPSA 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 8626
Gene Symbol: TP63
TP63 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 5713
Gene Symbol: PSMD7
PSMD7 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 10244
Gene Symbol: RABEPK
RABEPK 		0.010 GeneticVariation disease BEFREE We identified two patients with visceral leishmaniasis who had autosomal recessive IL-12 p40 and IL-12Rβ1 deficiencies, respectively. 27873456 2017
Entrez Id: 2153
Gene Symbol: F5
F5 		0.010 GeneticVariation disease BEFREE We here report a case of subacute Budd-Chiari syndrome (BCS) related to Factor V Leiden (FVL) mutation in the presence of visceral leishmaniasis. 15815883 2004
Entrez Id: 4519
Gene Symbol: CYTB
CYTB 		0.020 GeneticVariation disease BEFREE We evaluated the genetic composition and the patterns of genetic differentiation among Lu. longipalpis populations collected from regions with different patterns of transmission of visceral leishmaniasis by analyzing the sequence variation in the mitochondrial cytochrome b gene. 21936320 2011
Entrez Id: 5324
Gene Symbol: PLAG1
PLAG1 		0.010 Biomarker disease BEFREE We describe the immune humoral response against the PSA in dogs and human patients with visceral leishmaniasis caused by L. infantum. 10652117 2000